50. deganutti, g.; zhukov, a.; deflorian, f.; federico, s.; spalluto, g.; cooke, r. m.; moro, s.; mason, j. s.; bortolato, a., impact of protein-ligand solvation and desolvation on transition state thermodynamic properties of adenosine a(2a) ligand binding kinetics. in silico pharmacol 2017, 5 (1), 16.

Answers

Answer 1

The protein-ligand solvation and desolvation have an impact on the transition state thermodynamic properties of adenosine A 2A ligand binding kinetics. This is a true statement.

What is protein-ligand solvation?

As criteria for consideration in lead optimization and drug discovery become more important, so do the kinetic rates impact of Ligand protein solvation. SPR revealed intriguing discrepancies for the purpose of binding and unbinding events between the various ligands in the entropic and enthalpic components of the Transition state energy barriers.

In order to comprehend these procedures at the molecular level. A brand-new molecular dynamics (MD)-a based strategy called suMetaD combines supervised MD and metadynamics.

This technique aids in simulating the binding and unbinding of ligands. The largest energy barrier that the ligand must overcome to enter the final state correlates to the system conformation.

Therefore, this is a true statement.

Read more about protein-ligand interaction, here

https://brainly.com/question/24302302

#SPJ4


Related Questions

help asap 1st answer gets brainliest​

Answers

Answer:

it looks like it is B

Explanation:

Hope this helps!! :D

A combination of DNA and protein molecules that exists in a loose, web-like form is known as ________.
chromosomes
histones
centromeres
chromatin

Answers

Answer:

The answer is Chromosomes

Theres an old man needed your help but you are soo late in your work.What would you do?explain it briefly.​

Answers

Answer:

I will help him first

Explanation:

because it's our duty to help elders .

What type of macromolecule is an enzyme?

carbohydrate
lipid
protein
nucleic acid

Answers

A protein is an enzyme. The monomer for a protein is an amino acid. There are 20 types of amino acids. Most proteins are made of amino acids only.

development of continuous flow systems to access secondary amines through previously incompatible biocatalytic cascades

Answers

The use of continuous flow reactors enabled previously inaccessible enzyme combinations in multi-enzyme cascade reactions.

The combination of oxidases with aminating biocatalysts (transaminase/reductive aminase) and was extended to the continuous in situ biocatalytic generation of amino donors for the reductive aminase.

The reaction cascades described here started with the generation of aldehydes from stable and commercially available alcohols. As aldehydes are versatile yet unstable intermediates, it was thought a continuous flow system that generated this group in situ at high concentrations could allow for a range of subsequent enzymatic modifications. Biocatalytic oxidations are fundamental in transitioning to a bio-based economy, in particular the use of oxidases which carry out selective oxidation using molecular oxygen as the sole oxidant.

For the first time it has been shown that previously incompatible enzyme cascades can be run continuously, greatly improving the metrics (up to 58-fold for STY and 4-fold for enzyme productivity) when compared to the equivalent batch reactions. This system is extremely versatile with several enzyme combinations tested that enabled the generation of a range of amine intermediates. The reactors were also extended to demonstrate proof-of-concept, high throughput reaction screening in continuous flow. A continuous synthesis of the biologically relevant molecule 4O-methylnorbelladine was also successfully demonstrated. Using a continuous approach allows many additional benefits to those discussed here to further improve biocatalytic reaction efficiency.

To know more about "Secondary amines"

Refer this link:

https://brainly.com/question/9744866

#SPJ4

If an atom has an atomic number of 16, the number of electrons it would
have in its outer most shell would be

Answers

Hello it’s b bbbbbbb

Answer: PHOSPHORUS

Explanation:

The term atomic number, conventionally denoted by the symbol Z, indicates number of protons present in the nucleus of an atom, which is also equal to the number of electrons in an uncharged atom. The number of neutrons is represented by the neutron number (N)

im new to this so i tried what i knew

The cell membrane has____. a) polar heads on the outside and nonpolar fatty acids on the inside b) nonpolar fatty acids on the outside and a polar heads on the inside c) polar heads on both inside and outside d) nonpolar fatty acids on both inside and outside

Answers

Answer:

a) polar heads on the outside and nonpolar fatty acids on the inside

Explanation:

The cell membrane is made up of phospholipids arranged in a bilayer, where hydrophilic polar (negatively-charged) heads of phospholipids interact with water molecules (i.e., aqueous surrounding media). Moreover, non-polar (uncharged) fatty acid tails are hydrophobic because they cannot be dissolved in water. Thus, the bilayer cell membrane is a structure where non-polar fatty acid chains are localized in the inner region (away from the water), while hydrophilic phosphate heads face outward, interacting with water on both sides of the cell membrane.

What types of things is “medicinal marijuana” prescribed for?
Help ​

Answers

Answer:

anxiety

pain

Explanation:

Pain is the main reason medicinal marijuana is prescribed. It could also be prescribed to treat Crohn’s disease, Seizure disorders, nerve pain, muscle spasms caused by multiple sclerosis, or nausea from chemotherapy.

What would happen if sulfur was removed entirely?

Answers

Sulfur is essential for humans, animals and plants. When it enters our body, it can be incorporated into tissues such as skin and cartilage. It is also found in some proteins and vitamins. if the sulfur were completely removed, it causes several symptoms, such as depression, neuritis, unpleasant odor in the saliva and a decrease in the brightness of the skin. To avoid this deficit, it is recommended to eat fruits and vegetables. Foods of animal origin such as milk and eggs also have it in their constitution.

What is the role of sulfur in the human body?

Another great advantage of sulfur is that it has anti-inflammatory action, in addition to being an antioxidant. This means that it fights free radicals and also increases the body's defense against invading agents, preventing, for example, the flu. In addition, the mineral helps to detoxify the body.

With this information, we can conclude that Sulfur dioxide is a toxic gas that mainly affects the mucous membranes, acting on the respiratory system and eyes, causing irritation.

Learn more about sulfur in the human body in  brainly.com/question/1746602

#SPJ1

classify each electrolyte as an intracellular or extracellular anion (negatively charged ion) or cation (positively charged ion).

Answers

Electrolytes are substances that, when dissolved in water, conduct electricity. A variety of biological functions depend on electrolytes. They  acquire a natural positive or negative electrical charge.

What is intracellular or extracellular ions?

Electrolytes are classified as both  intracellular fluid and the extracellular fluid include electrolytes chemicals. The main cation and anion in extracellular fluid, respectively, are sodium and chloride.

Sodium is one of the most crucial electrolytes in the extracellular fluid because it is an active cation. It is in charge of regulating the cell's membrane potential, as well as maintaining the extracellular fluid volume.

All body tissues require the mineral potassium, which is a necessary component. Because it carries a little electrical charge that activates numerous cell and nerve activities, it is also referred to as an  extracellular anion.

Therefore, electrolytes are classified as intracellular or extracellular.

Learn more about electrolytes here:

https://brainly.com/question/9650191

#SPJ4

What phase of the cell cycle does DNA replication occur?

a
G1
b
S
c
G2
d
M
e
cytokinesis

Answers

Answer:

s phase

Explanation:

so the genetic material can double before it begins division

An increase in the membrane permeability for a solute will result in an increase in the driving force for diffusion of that solute through the membrane. True or false?.

Answers

A membrane's permeability has an impact on the diffusion rate. As membrane permeability increases, the diffusion rate rises.

The dispersion of materials is also impacted by changes in temperature and pressure values.The passive diffusion rate of penetrated molecules through the biomembrane can be used to quantify a membrane's permeability. It is well acknowledged that the permeability of any particular molecule depends mostly on its size, polarity, charge number, and molar mass.The capacity for materials to flow into and out of a membrane is known as permeability. The ease with which a chemical can diffuse across a cell membrane determines its permeability.Only chemicals that can dissolve in fat can typically pass through a cell membrane.The electrical potential gradient across the cell membrane and the concentration gradient of the permeant ion across the membrane together make up the net electrochemical driving force.

Learn more about permeability here:

https://brainly.com/question/14702319

#SPJ4

Which best describes a plasmid I’ll give brainliest pls

Answers

Answer:

Plasmids are used in biotechnology.  

Explanation:

A plasmid is a natural or artificially modified circular DNA molecule for use in biological research.

The researchers use the plasmids to insert a DNA fragment of interest, thanks to the cloning cassettes. They can clone genes to express proteins or RNAs and analyze them.

Answer:

A plasmid is a small, extrachromosomal DNA molecule within a cell that is physically separated from chromosomal DNA and can replicate independently. They are most commonly found as small circular, double-stranded DNA molecules in bacteria; however, plasmids are sometimes present in archaea and eukaryotic organisms

Explanation:

Each lunar cycle has one full moon, in which the relative positions of Earth, the sun, and the moon form in a straight line. Which list represents the position of Earth, the sun, and the moon during a full moon?

Answers

Answer:

b

Explanation:

Differences between epithelial and meristematic tissue.​

Answers

Answer: Epithelial tissue is the internal and external lining of the surfaces of organs. Connective tissue connects tissues and organs.

Explanation: Good Luck!

Answer:

1. A tissue which covers body surfaces such as lining of organs and skin, and tissue which plays role in secretion, protection and absorption is referred as Epithelial tissue.

A tissue which is composed of fibers, water, and adhesion proteins and which connects parts of body together, this is referred as Connective tissue.

2.It lines organ surfaces, the cavity, and blood vessels of the animal body.

It connects, and supports different organs and tissue in the body.

A order arrangement of properties is called

Answers

Answer:

its order of operations

What is the per capita growth rate of a population of 250, with 50 births and 80 deaths in a year?

Answers

The population will decrease by 30 every year this maybe wrong. If it is and you can specify more on the question I’d love to help.

sustainability can be excercised in the harvesting of many different natural resources describe how t

Answers

Fishing until reaching an established quota that allows the fish population to rebound each season is a method of sustainable fishing

What is sustainability ?

The main objective of sustainability is for people to live in peace and harmony on Earth for an extended period of time. Specific definitions of sustainability are difficult to agree on and hence vary in the literature and across time

Sustainability is often represented diagrammatically. The figure at the top of this page suggests that there are three pillars of sustainability – economic viability, environmental protection and social equity.

Sustainability is important for many reasons including: Environmental Quality – In order to have healthy communities, we need clean air, natural resources, and a nontoxic environment. Growth - UNTHSC's enrollment continues to expand, thus we demand additional resources such as energy, water, and space.

Learn more about Sustainability here:

https://brainly.com/question/4677073

#SPJ4

the capacity of a brain area to develop new neural pathways as it adjust to good and bad experinces is known as

Answers

The capacity of a brain area to develop new neural pathways as it adjust to good and bad experiences is known as Neuroplasticity.

Neuroplasticity also known as brain plasticity is defined as the ability of the nervous system to change its function and develop new pathways in response to new information.

Neuroplasticity is the changes that happen to the brain over the years. These changes depend on the new experiences which can be good or bad. It also depends on environmental influences, practice, and psychological stress.

Neuroplasticity play an important role for healthy development, learning, memory.

If you need to learn more about neuroplasticity, click here

https://brainly.com/question/689119?referrer=searchResults

#SPJ4

The capacity of a brain area to develop new neural pathways as it adjusts to good and bad experiences is known as neuroplasticity

Neuroplasticity is a broad term related to the brain's capacity to alter, modify, and adapt its function and structure across people's lives and in response to stimuli.

Individual differences in brain function and structure contribute to the variability observed in neuroplasticity mechanisms, which also show significant differences across individuals. Indeed, a growing body of recent research indicates that the guidelines and mechanisms governing cortical plasticity seem more dynamic than previously thought.

To learn more about neuroplasticity: brainly.com/question/13198261

#SPJ4

what directs the action of every cell in your body

Answers

Answer:

the nucleus of the cell

plz mark me brainliest

what did you learn about climate change new words new ideas new conepts

Answers

Climate change includes both the global warming driven by human emissions of greenhouse gases, and the resulting large-scale shifts in weather patterns

which organelle builds proteins

Answers

Answer:

I belive its ribosomes.....

Explanation:

HELP ASAP ILL GIVE BRANLIEST!!!!!

Answers

Answer:

What's ur question?

Explanation:

Answer:

You must give us a question so we can answer.

Explanation:

Which part of the mollusk body is specialized for burrowing,feeding , and movement

Answers

Answer:

The foot

Explanation:

Mollusks have bilateral symmetry and are coelomed protostomes, but the coelom is only represented by small residual spaces around the pericardial cavity, the gonads, some parts of the nephridia, and in some cases part of the intestine. The foot is used primarily as a means of movement. The foot is also a very important structure, although it has adapted differently depending on the classes of mollusks. It is characterized by having a really powerful and complex musculature. The most widespread use of this organ is that of locomotion, as happens with gastropods. However, in bivalves it serves to burrow or in cephalopods it helps to provide propulsion.

Invertebrate animals with the unsegmented soft body which is enclosed in shells made up of calcium carbonate are called Mollusca.

The part of mollusk's specialized in feeding, burrowing and movement are:

Foot

The Mollusca can be explained as:

The Mollusca have the bilateral type of symmetry and coelomate protostomes which are visible as residual spaces surrounding the pericardial cavity, nephridia and gonads.

The foot is the part that is used in locomotion and is adapted differently for various purposes in various forms of Mollusca.

It has a complex musculature and helps in propulsion, as a mode of feeding appendage and in some for burrowing purposes.

Therefore, the foot is a specialized organ.

To learn more about the foot of Mollusca follow the link:

https://brainly.com/question/9174538

the epigastric region is a portion of the cavity. multiple choice pelvic pleural vertebral abdominal

Answers

The epigastric region is a portion of the abdominal cavity.

The correct option is d.

The greatest hollow area in the body is the abdominal cavity. Its lower limit is the upper plane of the pelvic cavity, and its upper barrier is the diaphragm, a sheet of muscle and connective tissue that divides it from the chest cavity. The spinal column, as well as the abdomen and other muscles, encircle it vertically.

The epigastrium is the top portion of your abdomen that is immediately below your rib cage. The epigastrium houses your pancreas and the duodenum, a section of your small intestine. Additionally, your stomach and liver are partially located here.

To learn more about epigastric region, refer

https://brainly.com/question/28237650

#SPJ4

Why were garden peas a good choice for a study of heredity?

Answers

Answer:

pea plants because they were easy to grow, could be bred rapidly, and  several observable characteristics, like petal color and pea color.

Explanation:

One half of a duplicated chromosome is called:
Telomere
Chromatid
Chromatin
Centromere

Answers

The Answer is Chromatid

One half of a duplicated chromosome is called Chromatid. The correct option is B.

Thus, A chromatid is the name for the duplicated half of a chromosome. The chromosome is duplicated during DNA replication, creating two identical copies known as sister chromatids.

The centromere, a particular area, is what holds these sister chromatids together. A complete set of DNA molecules or genetic material can be found in each chromatid. During cell division, the sister chromatids split apart to form individual chromosomes, which are then dispersed to the daughter cells.

Contrarily, the telomeres are specialized structures found at the ends of chromosomes that aid in maintaining the DNA's integrity during replication and guard against deterioration.

Thus, One half of a duplicated chromosome is called Chromatid. The correct option is B.

Learn more about Chromatid, refer to the link:

https://brainly.com/question/30667218

#SPJ6

environmental factor in fresh water, ocean trench, hot springs, terrestrial and problems caused for each ​

Answers

Answer:

sorry don't know but I need points plese mark me as brainlest

Explanation:

I want free points

WILL GIVE BRAINLIEST!!!!!!!
Which is not a function of cholesterol within the cell membrane?

Reduces permeability to some solutes

Reduces membrane fluidity

Prevents crystallisation of the membrane at low temperatures

Transports molecules across the cell membrane

Answers

Answer:

c

Explanation:

The function of cholesterol within the cell membrane maybe be many, but does not include the reduction in membrane fluidity .

The steric structure of the cholesterol in the cell membrane is such that:

it prevents freezing of the membrane when the temperature gets lowIt limits the permeability of some materialsit makes the membrane more fluid and stableit helps take up cholesterol from the surrounding environment into the cell, hence, helps with the transport of molecules.

The correct answer as to which is not a function of cholesterol within the cell membrane would, therefore, be that it reduces membrane fluidity.

More about the functions of the cholesterol in the cell membrane can be found here: https://brainly.com/question/1318903

4. What is an energy pyramid? Why is there a loss of energy at each level
moving up?

Answers

Answer:

#1 An ecological pyramid is a graphical representation designed to show the biomass or bioproductivity at each trophic level in a given ecosystem.  And #2 Most of the food energy that enters a trophic level is "lost" as heat when it is used by organisms to power the normal activities of life. Thus, the higher the trophic level on the pyramid, the lower the amount of available energy.

Explanation:

Other Questions
help it due in 4 mins please in mrs. middleton's math class, there are 7 more boys than girls. if there are 29 total students in the class, how many boys are there? A box of candy weighs 4 and 7/10 pounds. 2/5 get dumps out of the box. What is the weight of the candy left in the box? Help me to answer this..Click the picture to see the full question. a game arcade consists of a balloon that is inflated little-by-little during each round of play. The player wins when the balloon pops. The amount of air that is needed to make the balloon pop can be modeled bya. uniform distribution on the interval from 25 to 35 cubic inches of air. rosenheck ra, neale ms. cost-effectiveness of intensive psychiatric community care for high users of inpatient services. archives of general psychiatry. 1998;55(5):459-466 A homesteaded A homesteaded property is located in Jupiter, Florida, in Palm Beach County. The property has been assessed at $185,000. The city tax rate is 8.8 mills, the county tax rate is 9.3 mills, and the school board levy is 6.5 mills. The owner is a widow and has qualified for and received homestead tax exemption. How much will the owner pay in property taxes?property is located in Jupiter, Florida, in Palm Beach County. The property has been assessed at $185,000. The city tax rate is 8.8 mills, the county tax rate is 9.3 mills, and the school board levy is 6.5 mills. The owner is a widow and has qualified for and received homestead tax exemption. How much will the owner pay in property taxes How much kinetic energy does a 3.50kg block with a speed of 4.00m/s have? Tree teenage learners at your school A, B, C and D are junctions on a motorway.A B C Ddistance CD= 3 x distance ABdistance BC= 25 milesSalma drives from A to C.She drives for 30 minutes at an average speed of 62 miles per hour.Work out the distance AD.Not drawnaccurately Which statement best compares the use of imagery and color in the poem and artwork to portray the woman?The artworks use of color presents a woman of vigor and action, while the poem does not.The poem portrays the woman as unrefined, while the painting presents her as cultured.The artwork suggests a woman in her home, while the poems figurative language connects her to nature.The poem suggests that the woman is aloof, while the painting shows her to be self-absorbed. is 7.69 x 24^8 in scientific notation how much do language models copy from their training data? evaluating linguistic novelty in text generation using raven sinking fund provisions sometimes turn out to adversely affect bondholders, and this is most likely to occur if interest rates decline after the bond was issued A man runs at 7.5 m s-1 due east across the deck of a ship which moves at 10.0 m s-' duenorth. Determine the resultant velocity of the man (his velocity relative to the water). Vectors u and v are shown on the graph.Which of the following vectors represents v u? Using 6. 01024 kg for the mass of the earth, what is the acceleration of the earth toward her as she accelerates toward the earth with an acceleration of 9. 8 m/s2 ? assume that the net force on the earth is the force of gravity she exerts on it. what is an ancient civilization? How many two-ninths are in eight-ninths? MP Attend to Precision Trent writes 10 x 6 = 60 to findthe number of muffins in 10 boxes. Describe what each ofthe factors represents in the multiplication equation.