Describe the typical principles used to identify topogenic sequences within proteins and how these principles can be used to develop computer algorithms. How does the identification of topogenic sequences lead to prediction of the membrane arrangement of a multipass protein

Answers

Answer 1

Answer:

Topogenic sequences share a series of structural features, and thereby computational algorithms can be used to predict these protein-membrane segments  

Explanation:

Topogenic sequences are protein segments formed by alpha-helical transmembrane domains, which are required for the insertion of membrane proteins. These domains share a series of well-defined features: they are composed of segments of about 20 hydrophobic amino-acid residues. In consequence, computational algorithms can be designed to identify protein patterns that fulfill these structural requirements (i.e. segments with a length of 20 residues, hydrophobic level, etc). The models assign a similarity threshold (threshold value) that predict if the similarity level of the protein pattern is good enough to detect a topogenic segment.


Related Questions

What's the difference between Columnar Epithelium and Glandular Epithelium. (Pls answer fast T_T) ​

Answers

Answer:

glandular epithelium are specialized for secretion. lining epithelium simply lines organs like the stomach. ... Endocrine glands release substances within the body and exocrine glands release substances outside the body.

Simple columnar epithelia are tissues made of a single layer of long epithelial cells that are often seen in regions where absorption and secretion are important features. The cells of this epithelium are arranged in a neat row with the nuclei at the same level, near the basal end ...

SCENARIO ABiological anthropologists have discovered a previously unknown fossil species namedAustralopithecus sediba. The species lived about 2 million years ago in Africa and has an interesting mix of traits. For example, its arms are adapted for climbing in trees and its legs are adapted for walking on two legs on the ground. It does not directly resemble any of the living ape species, which suggests that the living ape species (including humans) have each become adapted for their own environmental contexts over time.What is the primary type of biological anthropology addressed in this research?A. Human biologyB. Forensic anthropologyC. PaleoanthropologyD. PrimatologyDoes the research also touch on topics that might be relevant to researchers in disciplines outside anthropology, such as biology, geology, psychology, medicine, sociology, or criminology? Which of the following disciplines would be most relevant?A. PsychologyB. BiologyC. CriminologyD. SociologyHow does this research relate to human evolution? In other words, what can we learn about human evolution from research along these lines?

Answers

Answer:

In scenario A A. Human biology

Which of the following disciplines would be most relevant?

B. Biology

Explanation:

In scenario A Australopithecus sediba arms are adapted for climbing in tree and its legs are adapted for walking on two legs. Australopithecus is related to homo habilis and also homo erectos. They are different human primate.

B. Biology because there are fossil remains dated to about 2 million years ago.

What happens to grasslands and wetlands as forests are used up?

Answers

Answer:

they dry

Explanation:

because forests are sources of rain and without rain wetlands can't have water and grass can't grow n grassland

Answer:

they become really dry good luck men

how does the nonpolar nature of lipids contribute to their insulating quality

Answers

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon–carbon or carbon–hydrogen bonds. ... Lipids also provide insulation from the environment for plants and animals hope this helps

A cell has two pairs of submetacentric chromosomes, which we will call chromosomes IA, IB, IIA, and IIB (chromosomes IA and I B are homologs, and chromosomes IIA and IIB are homologs). Allele M is located on the long arm of chromosome IA and allele m is located at the same position on chromosome IB. Allele P is located on the short arm of chromosome IA, and allele p is located at the same position on chromosome IB. Allele R is located on chromosome IIA and allele r is located at the same position on chromosome IIB.

A. Draw these chromosomes, identifying alleles M, m, P, p, R, and r as they would appear in metaphase I of meiosis. Assume there is no crossing over.

B. Taking into consideration the random separation of chromosomes in anaphase I, draw the possible types of gametes that might result from this cell’s undergoing meiosis. Assume that there is no crossing over.

Answers

Answer:

A) Allelic position in the chromosomes:

IA  ----------M------------:-----------P----

IB  ----------m------------:-----------p----

IIA -----------------R--------------------:---------------------

IIB -----------------r---------------------:---------------------

B) Types of gametes (assuming there is no crossing over):

MPR; MPr; mpR; mpr.

Explanation:

In submetacentric chromosomes, the centromere is located near to the middle of the chromosomes.

Since these two pairs of homologous chromosomes do not undergo crossover, the resulting gametes after meiosis may have four (4) allele combinations.

Look at the ocean system described below.
plankton
herring
octopus
shark
What will most likely happen to this ecosystem if the herring are killed by a
virus?
A. The shark population will increase.
B. The plankton will die off over time.
C. The octopus population will increase.

D. The octopus and shark populations will decline.

Answers

Answer:

I think the ans is D (The octopus and shark populations will decline.)

Most likely happen to this ecosystem if the herring are killed by a

virus D. The octopus and shark populations will decline.

What is a ecosystem?

An ecosystem is a geographic area where plants, animals, and other organisms, as well as weather and landscapes, work together to form a bubble of life.

What is importance of ecosystem?

As a society, we depend on healthy ecosystems to do many things; to purify the air so we can breathe properly, sequester carbon for climate regulation, cycle nutrients so we have access to clean drinking water without costly infrastructure, and pollinate our crops so we don't go hungry.

To learn more about An ecosystem, refer

https://brainly.com/question/21299195

#SPJ2

Difference between Squamous epithelium and Stratified epithelium. (Pls answer quick) ​

Answers

Answer:

squamous epithelium consists of a single layer of flat cells. It is found in lungs,heart and blood vessels.It allows the movement of materials across it.

stratified epithelium has many layer of flat cells.It is present in lining of oesophagus and mouth and also over the skin

In a simple epithelium the cells form a single layer and are all attached to the basement membrane. A stratified epithelium consists of multiple layers of cells in which only the basal layer is attached to the basement membrane. Hope it helps

_________16. Which one of the following should NOT be associated with electron transport chain?
A. Absorption of solar energy C. Movement of H+
B. Formation of ATP D. Cytochromes

Answers

The answer to this question will be movement of H+

I need the answers to this question super quick!! Thank yoh

Answers

Answer:

They are "anti" condons or "stop" condons

Explanation:

24. Explain why water shortages occur frequently in
parts of New York State even though the water
supply is nearly constant. [1]

Answers

Answer:

Water is an essential element of life. Water is life and it has a lot of functions such as for drinking and other domestic purposes. There could however be water shortage in some parts of Nee York states as a result of country as a result of the effects of drought due to low amount of rainfall in the area.

There may also be issues with the various instruments which helps in the transport of water to homes which could also lead to the shortage.

Shortages occur frequently in parts of New York State even though the water supply is nearly constant as there are some issues with the water transport system and also low rainfall in some areas.

What is the way of water transportation?

There can be several methods by which water transportation can be made easy.

Methods of transportation are included under three categories:

Aqueducts: it involves pipelines, canals, tunnels and bridges. Container shipment: it involves tank truck, tank car, and tank ship. Towing: it includes a tugboat is used to pull an iceberg or a large water bag along behind it.

Shortages occur frequently in parts of New York State even though the water supply is nearly constant as there are some issues with the water transport system and also low rainfall in some areas.

Thus, this can be the reason behind water shortage in New York.

For more details regarding water transport, visit:

https://brainly.com/question/10697816

#SPJ5

which organ of the body doesn't rest?​

Answers

Answer:

Brain

Explanation:

It is always active, and regulates everything going through your body. Even when your asleep, it makes sure that the body is in the right temp, and that all the organs help stay safe.

Answer:

The brain!

Explanation:

The body rests during sleep, not the brain. The brain remains active, gets recharged, and still controls many body functions!

Why is axon covered in insulated sheath?

Answers

Answer:  Myelin Sheath. The Myelin Sheath of a neuron consists of fat-containing cells that insulate the axon from electrical activity. This insulation acts to increase the rate of transmission of signals. A gap exists between each myelin sheath cell along the axon.

Explanation:. Myelin can greatly increase the speed of electrical impulses in neurons because it insulates the axon and assembles voltage-gated sodium channel clusters at discrete nodes along its length. Myelin damage causes several neurological diseases, such as multiple sclerosis.

Answer:

Myelin Sheath. The Myelin Sheath of a neuron consists of fat-containing cells that insulate the axon from electrical activity. This insulation acts to increase the rate of transmission of signals. A gap exists between each myelin sheath cell along the axon.

HOPE IT HELPS : D

Explanation:

2. Mr. Simpson has blood type ABRh+ and his wife type ORh+. Mr. Doodle has type ARh- and his wife type ORh+. The Simpsons and Doodles each had a baby girl on the same day. When they took their children home, their doctors found that the Doodle girl had blood type ARh- and the Simpson girl had type ORh+. The Simpsons sued the hospital for giving them the wrong baby. Could they win the case? Show the most likely genotypes of the parents and of the 2 girls

Answers

ORh+
AbRh+
Because the circumference of the earth and yes it will cause that

What are the fundamental parts of a typical cell

Answers

A cell consists of these three main parts: the cell membrane, the nucleus, and, between the two, the cytoplasm.

Answer:

the parts include Cell Membrane, Mitochondrion, Lysosome, Rough Endoplasmic Reticulum.    

Explanation:

the cell membrane Is made out of phospholipids and proteins

the Mitochondrion Site of cellular respiration "power house"

the Lysosome S.uicide Sacks that contain digestive enzymes

rough Endoplasmic Reticulum contains Ribosomes, transports proteins

hope this helped!

Consider a simplified metabolic model to describe nitrogen metabolism in the body. Nitrogen is ingested in the food (F), a fraction of which is actually absorbed (A), the remainder being lost in the feces (W). The absorbed nitrogen is taken up by the muscle to make protein. At small fraction of the stored muscle protein undergoes degradation and the liberated nitrogen (L) is released from the muscle. Of the liberated nitrogen, a fraction is recycled back to the muscle (R), while the rest is lost to excretion (E) in the urine

Answers

The given question is incomplete, the complete question is:

Consider a simplified metabolic model to describe nitrogen metabolism in the body. Nitrogen is ingested in the food (F), a fraction of which is actually absorbed (A), the remainder being lost in the feces (W). The absorbed nitrogen is taken up by the muscle to make protein. At small fraction of the stored muscle protein undergoes degradation and the liberated nitrogen (L) is released from the muscle. Of the liberated nitrogen, a fraction is recycled back to the muscle (R), while the rest is lost to excretion (E) in the urine. If the nitrogen ingested in food is 100 g/day, but only 80% of the food is actually absorbed, while the rest goes to waste, what is the amount of nitrogen lost by excretion? Assume steady-state. Of the nitrogen liberated from muscle, 90% is excreted, while the rest is recycled, what fraction of the nitrogen entering the muscle is from the absorbed food? (In other words, what is the ratio A/(A+R)). Again, assume steady-state

Answer:

The amount of nitrogen lost in the process is 20 grams in a day and the fraction of nitrogen entering the muscle is 0.909.

Explanation:

Based on the given question, the amount of nitrogen absorbed is 80 percent of 100 grams, that is,  

100*(80/100) = 80 grams in a day.  

The concentration of nitrogen lost in the process is,  

Nitrogen ingested-nitrogen absorbed = 100-80 = 20 grams in a day.  

Let us assume that all the ingested nitrogen is liberated from the muscle. Therefore, 80 grams of nitrogen is liberated. If 90 percent of the nitrogen liberated from the muscle get excreted, then the value of excreted nitrogen will be,  

90% of 80 grams = 90/100*80 = 72 grams

Now the nitrogen recycled will be,  

Liberated nitrogen - excreted nitrogen = 80-72 = 8 grams

From the absorbed food, the fraction of the nitrogen entering the muscle will be,  

80/(80+8) = 80/88 = 0.909.  

Select the choices that best complete the following sentence: An inherited feature of an organism is a ______ whereas a variant of that feature is called a ______.
A.
homozygote; heterozygote
B.
chromosome; factor
C.
hybrid; gamete
D.
character; trait
E.
allele; gene

Answers

Answer:

A

Explanation:

Homozygous means that both copies of a gene or locus match while heterozygous means that the copies do not match. Two dominant alleles (AA) or two recessive alleles (aa) are homozygous. One dominant allele and one recessive allele (Aa) is heterozygous.

what type of epithelium has dome shaped on the apical surface? ​

Answers

Answer:

Transitional epithelium has dome shaped cells on the apical surface.

Answer:

Transitional epithelium

Transitional epithelium has dome shaped cells on the apical surface. Pseudostratified epithelium is a type of epithelium that has cells which all touch the basement membrane. Pseudostratified epithelium is only one cell layer thick.

HOPE IT HELPS XD

Explanation:

Each phospholipid is made up of:
A. Two phosphate groups and one fatty acid chain.
B. A phosphate group and two fatty acid chains.
O
C. A phosphate group and a fatty acid chain.
O
D. Two phosphate groups and two fatty acid chains.

Answers

Answer:

The correct answer is B. A phosphate group and 2 fatty acid chains.

Explanation:

A P3 X

Each phospholipid is made up of a phosphate group and two fatty acid chains. The correct option is B.

What are phospholipids?

Phospholipids are lipids that have two types of edges. It has a hydrophobic tail and a hydrophilic head.  The plasma or cell membrane, according to the fluid mosaic model, comprises substances like proteins and phospholipids.

A phosphate head and a fatty acid (lipid) tail make up the phospholipid layer, also known as the phospholipid layer, which is formed by the phospholipid.

Small molecules like oxygen gas can diffuse through the phospholipid layer, which facilitates the passage of small molecules but not larger ones. Biological membranes are formed by two lipid layers, proteins, and glucans.

Therefore, the correct option is B. A phosphate group and two fatty acid chains.

To learn more about phospholipids, refer to the link:

https://brainly.com/question/2614136

#SPJ2

In rabbits, brown coat (B) is dominant to white coat (b). A rabbit breeder wants to know the genotype of his best looking male brown rabbit using a test cross. He has brown females and white females available to conduct his breeding experiments.

Required:
a. What should be the coat color of the female he must use in this test cross?
b. If the test cross produces seven (7) brown rabbits and one (1) white rabbit, what is the genotype of the brown male rabbit?

Answers

Answer:

a. white

b. Bb

Explanation:

A test cross usually involve crossing an individual whose zygosity is unknown with a homozygous recessive version of individual of the same species.

Brown coat (B) is dominant over white coat (b). Hence, there is no way to physically distinguish between a BB rabbit and a Bb  rabbit because both of them will be brown. A bb rabbit however will be white in appearance.

A test cross would therefore involve crossing the brown male rabbit with bb (white) rabbit.

Assuming that the genotype of the brown rabbit is BB, all the progeny will be brown as shown by the cross below.

         BB   x   bb

    Bb   Bb   Bb   Bb

In order word, assuming the genotype is Bb, some of the offspring will appear brown while some will appear white.

      Bb  x   bb

Bb   Bb   bb   bb

Hence, the only way the test cross would produce white offspring is if the genotype of the brown rabbit is heterozygous, Bb.

Chemical equilibrium results if_____.

Answers

Answer:

what he said ^

Explanation:

i think...

Which of these factors will affect the friction on a road?
a) Oil
b) Water
c) Ice
d) all of the above

Answers

Answer:

all of the above

Explanation:

Oil,Water and Ice

all of these will affect the friction on the road.

hope this helps

brainliest appreciated

good luck! have a nice day!

Answer:

D-all of the above

Explanation:

Force of friction is the force which opposes the motion of an object over a surface

The force of friction acts between the object and the surface.

A ball rolling on ground gradually slows down and comes to rest due to force of friction between the ball and the ground.If we stop pedaling a bicycle, it gradually slows down and comes to a stop due to force of friction between the wheel and the road.

Where does the Energy from plants originally come from?

Answers

Answer:

In plants, these energy factories are called chloroplasts. They collect energy from the sun and use carbon dioxide and water in the process called photosynthesis to produce sugars. Animals can make use of the sugars provided by the plants in their own cellular energy factories, the mitochondria.

hope ti helps please mark me brainliest XD

Explanation:

reaaallly need help!!​

Answers

Explanation:

this is very easy I will try and send this picture

. Why did Jim decide to move his lab to New York? a) he wanted to be near where the trials were occurring b) he wanted to be closer to his family c) the pharmaceutical company demanded it

Answers

Answer:

a) he wanted to be near where the trials were occurring

Explanation:

hope it helps .

what is 9 + 10??? VERY IMPORTANT

Answers

Answer:

9 + 10 = 19

the answer is = 19

What explains the presence in living humans of DNA sections which are identical to DNA
found in Neanderthals who lived 40 000 years ago?

Answers

Answer:

It can be explained by hybridization among human and neanderthal ancestral populations.

Explanation:

Next-generation sequencing (NGS) technologies coupled with bioinformatics tools have enabled to confirm admixture between Neanderthals and humans. The technique to identify admixture events consists in discovering nucleotide regions from neanderthal genomes that could be inserted in human genomes, thereby the observed sequence homology must be statistically significant (e-value). This emergent research field is known as paleogenomics.

How can you determine the optimum pH of an enzyme?

Answers

The optimal pH can be measured by looking at enzyme activity verses pH. Enzyme activity will increase up to a certain pH; above that pH, the enzyme activity will begin to fall.

You can determine the optimum pH of an enzyme by graphing its pH activity and studying the results.

Enzymes each perform differently in distinct environments. Some require lower pH to function, while others achieve maximum performance at higher pH levels.  

This relationship between the productivity of the enzyme and the pH can be studied and graphed. Once done, we can expect this graph to look like a parabola, increasing steadily until maxed, then gradually decreasing back to zero at the other extreme. The vertice of this parabola will give us the optimum pH for the enzyme.

To learn more:

https://brainly.com/question/1255435?referrer=searchResults

During digestion fat is broken down into

Answers

Answer:

Lipase

Explanation:

Lipase enzymes break down fat into fatty acids and glycerol. Digestion of fat in the small intestine is helped by bile, made in the liver.

You have isolated a new mutation in the T4 bacteriophage rII A gene and you map its location within the gene by recombination frequency. You find that this new mutation fails to give wild type recombinants with several different adjacent mutations located in the same gene. What type of mutation is this new one you just isolated

Answers

Answer:

A lethal mutation, thereby the resulting phenotype is not observed .

Explanation:

Lethal mutations are the result of genomic changes that may be lethal in certain conditions. In genetic research, this type of mutation has shown to be very useful in analyzing gene function (i.e., genes whose protein products are key for the survival of the organism in question), and they are perfect gene markers. In bacteriophages, for example, temperature-sensitive mutants of phage T4 that can not grow at temperatures higher 42°C have been identified (Edgar & Lielausis 1964).

Citation:

R. S. Edgar, & I. Lielausis (1964). Temperature-sensitive mutants of bacteriophage T4D: their isolation and genetic characterization. Genetics, 49(4), 649.

What impact does the atmosphere have on the Earth's cycles? Select four options,
produces wind currents
transfers nitrogen from air to soil
transfers water into Earth's oceans
moves oxygen from volcanic eruptions for plants
moves oxygen and carbon dioxide through the biosphere?

Answers

Answer:

D

Explanation:

I think the atmosphere facilitates the distribution of oxygen and co2

Answer:

D

Explanation:

Other Questions
Which characteristics does a civilization have? Hola amigos! Me llamo Rubn Suarez y vivo en el pueblo de Mendoza, Argentina. Hoy es sbado y mi padre est enfermo. Yo ayudo a mi padre a hacediligencias hoy. Mi padre me dice en su lista de diligencias: > A las siete de la noche, la tienda de mi padre seMi primo Humberto vive en los Estados Unidos. Su mam es estilista los sbados. Los fines de semana, mi primo maneja y devuelve los libros a la biblictambin recoge la ropa en la lavandera. Despus de hacer las diligencias a las tres de la tarde, compra carne en el supermercado y cena una hamburgmadreBased on the text, what's a similarity between Rubn and Humberto?A-The length of all the errands they assist withB-The specific family situation they experienceC-The type of traditional food they eat with the familyD-The transportation they use to do errands In which region of North America did the Great Awakening begin?A. the SouthB. the MidwestC. New EnglandD. the Pacific Northwest A rectangular deck is 12 ft by 14 ft. When the length and width are increased by the same amount, the area becomes 288 sq. Ft. How much were the dimensions increased? which best describes a mixture.A it has a single composition and it has a set of characteristics B it can have different compositions but it has a set of charactaristics that does not changeC it has a single composition but it has a set of characteristics that does changeD it can have different compositions and it has a set of characteristics that does change differentiate (2x+1) (x-1) Factor::x^2+8x-20thank youuu How do you see the ancient Vedic period may have influenced the Bhakhi movement? Wuthering Heights: Do you agree or disagree with these statements? Explain why!1. Heathcliff was truly wicked with no good qualities.2. Although Heathcliff is often violent, we still feel sympathy for him.3. Catherine married Edgar for all the right reasons.4. Hindley was just a bad person as Heathcliff.5. Ellen Dean was the nicest person in the story. Which explains why the reflex reaction is important in certain situations?O A. Motor neurons cannot form action potentials.O B. The brain has no control over motor neurons.O C. Interneurons are too slow at sending signals through the spinalcord.O D. Sensory neurons do not use neurotransmitters to send signals. PLEASE HELP! ITS DUE TODAAY! 10. Which of the following groups of organisms are prokaryotic? (Choose all that apply)Archaea Or Plants Or bacteria Or fungi I really need help with this question someone plz help ! A day trader buys an option on a stock that will return $150 profit if the stock goes up today and lose $650 if it goes down. Complete parts a and b below given that the trader thinks there is a 70 % chance that the stock will go up. a) What is her expected value of the option's profit?b) What do you think of this option? The region labeled with the number 1 on the map above is? A. Eastern Siberian highlights B. Central Siberian plateau C. Western Siberian plain D. Ural mountain But when a long train of abuses and usurpations, pursuinginvariably the same Object evinces a design to reducethem under absolute Despotism, it is their right, it is theirduty, to throw off such Government, and to provide newGuards for their future security. - Such has been thepatient sufferance of these Colonies; and such is now thenecessity which constrains them to alter their formerSystems of Government.Why was the above passage included in the declaration of Independence?A. To identify the improvements made on the Articles ofConfederationB. To elaborate on the colonists' preference for democracyC. To explain that forming an independent nation was a last resortfor the colonistsD. To argue that other British subjects should also declare.themselves independent Which of the following quotes from Heart of Darkness contains sarcasm?A. Marlow says that an uncivilized place "has a fascination...of the abomination."B. Marlow calls an African soldier who works for the colonialists "one of the reclaimed."C. Marlow says, "There was a touch of insanity" in the sight of a warship firing at a continent.D. Marlow calls colonialism " a flabby, pretending, weak-eyed devil of rapacious pitiless folly." A cord is wrapped around the outer surface of the 8-kg disk. If a force of F = (14u2) N, where u is in radians, is applied to the cord, determine the disks angular acceleration when it has turned 5 revol 2x - 15x+9For what value of x would the expression be undefined Which trinomial did she factor?x2 + 4x 12x2 + 2x - 6x2 - 8x - 6x2 - 4x - 12