energy restriction mimetic agents to target cancer cells: comparison between 2-deoxyglucose and thiazolidinediones pdf

Answers

Answer 1

There is the  use of energy restriction mimetic agents (ERMAs) to selectively target cancer cells which are addicted to glycolysis and  could be a promising therapeutic approach.

Thiazolidinediones (TZDs) are synthetic agonists of peroxisome proliferator-activated receptor (PPAR)γ that were developed to treat type II diabetes.

These compounds also display anticancer effects which appear mainly to be independent of their PPARγ agonist activity but the molecular mechanisms involved in the anticancer action are not yet well understood. Results obtained on ciglitazone derivatives, mainly in prostate cancer cell models, suggest that these compounds could act as ERMAs.

2-Deoxyglucose as an energy restriction mimetic agent: effects were on mammary carcinogenesis and on mammary tumor cell growth in vitro.

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Related Questions

explain why bacteria, in particular, are very useful organism in the process of genetic engineering​

Answers

Answer: The bacterial cells are being used in order to create genes and produce human insulin. The bacteria is used to make protein, which is a good thing. I hope this at least helped, and I believe this is why bacteria is useful organism in the process of genetic engineering.

What part of the cell allows the corona vīrus to enter?

Answers

Answer:

The cellular membrane

Explanation:

Which of these is NOT an
example of insulator?
A. rubber pot holder
B. cloth curtains
C. aluminum foil

Answers

Answer:

ITS A Rubber pot holder

Explanation:

cauze rubber don't pass electricity...

Hope it helps :)

There is a large number of mitochondria in cardiac muscle cells because cardiac muscles need the mitochondria to:
1)work harder and longer.
2)maintain their shape.
3)maintain their color.
4)be attached to the ribs.

Answers

Answer:

to work harder and longer

Answer:

a. work harder and longer.

Explanation:

the chemical formula for water is

Answers

Answer: The chemical formula for water is H2O!

Answer:

H2O

Explanation:

H2O

What is the name of this leaf​

Answers

Answer:

A beam leaf

Explanation:

How do simple diffusion and facilitated diffusion differ?

Answers

Answer:

Simple diffusion does not require energy: facilitated diffusion requires a source of ATP. Simple diffusion can only move material in the direction of a concentration gradient; facilitated diffusion moves materials with and against a concentration gradient.

Explanation:

What must occur for protein translation to begin?

Answers

Translation starts at the three-base codon for the amino acid methionine in almost every known instance. The sequence of this codon is AUG. Both protein and RNA components can be found in the two subunits that make up proteins. The smaller ribosomal subunit's responsibility is to identify the AUG codon, which will serve as the beginning of translation (called the initiation codon). Finding the proper AUG is not an easy task, even though always starting at AUG helps alleviate the reading frame problem. When there are many AUG codons in an mRNA, the small ribosomal subunit must identify the proper one in order to produce the desired protein.

what is percentage of oxygen of inhaled air​

Answers

Answer:

21%

I hope this helps!

Please answer it’s due at 4!!!!!!!!??

Answers

Answer:

sexual reproduction

Explanation:

Try not to say the time, because we are not the same time zone.

we are different countries;) lol

It is sexual reproduction

which indicator, when considered in conjunction with the ecological footprint, would provide the most information about environmental impact?

Answers

Human population would provide the most information about environmental impact.

Population- A population is the total number of people living in a certain region. The entire number of residents makes up a city's population. Residents or occupiers are the terms used to describe them. The population of an area consists of everyone who lives there.

Environment- The surroundings, things, or situations in which one finds oneself. The combination of biotic (living things) and abiotic (Non-lining)  (temperature, soil, etc.) elements that affect an organism or ecological community and ultimately decide its shape and survival.

Organism- A living thing made up of one or more cells and able to carry on the activities of life (as using energy, growing, or reproducing)

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What is the final step of the cell cycle, directly following mitosis?

Anaphase
Cytokinesis
Interphase
Metaphase

Answers

Answer:

Cytokinesis

hope it help u :)

What type of infection is transmitted by athlete’s foot?

Bacterial
Fungal
Parasitic
Viral

Answers

Answer:

Fungal

Explanation: took the test!! :)

Fungal, Because the athlete's foot is a fungus, and is transmitted to an athletes foot. Hope it helps

the dysregulation of hormones may affect several pathways and processes in their body, which leads to risk in the emerging possibility for type ii diabetes, cardiovascular disease, infertility.

Answers

The most prevalent hormonal illness, polycystic ovarian syndrome, mostly affects adolescent girls as their hormonal balance and menstrual regularity mature.

Anovulation, dysmenorrhea, and amenorrhea are caused by the variability of menstrual hormones and other causes.The dysregulation of hormones may have an impact on a number of physiological pathways and functions, increasing the risk of type II diabetes, cardiovascular disease, and infertility.Genetics, neuroendocrine, lifestyle/environment, and obesity are among the risk factors that predispose people to PCOS. The pathophysiology of PCOS primarily focuses on hormonal disruption, insulin resistance, and hyperandrogenism causing poor folliculogenesis and increasing the risk of related comorbidities such endometrial cancer and type II diabetes.

The explanation of potential treatments for controlling the syndrome coupled with lifestyle adjustment, which can be used singly or in combination depending on the symptoms.

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Your question seems incomplete, please find the complete question below:

Discuss the effects of hormonal dysregulation in humans.

I need help please ​

Answers

Answer:

75 percent, 25 percent

Explanation:

which of the following is a function of the nucleus.
stores sugar
packages proteins
stores dna
builds proteins.

Answers

Stores sugar maybe or builds proteins

Answer:

Stores DNA.

Explanation:

The nucleus is the control center of the cell.

Which characteristic of sound makes it possible for bats to fly in the dark without hitting any objects?

Answers

Answer: echo location

Explanation:

Decomposers, detrivores, and scavengers feed on dead organic material. How are decomposers different from scavengers and detrivores?.

Answers

Answer:

Okay, so a detrivore is a type of decomposer.

Basically, scavengers eat their food while decomposers do not eat the food, but instead break it down further externally.

The difference between a decomposer and the scavenger is that the scavenger is the one that consumes dead plants, animals or carrion to break down the organic materials into small particles.

The decomposer instead consumes the remains produced by the scavengers.

Examples of decomposers can be bacteria and fungi.

Examples of scavengers can be animals (like insects, birds, little critters)

Explanation:

Make a claim about which organism(s) use carbon dioxide and which organisms) produced carbon dioxide. How did your test conditions affect the cycling of matter between plants and animals?
Evidence: Describe specific observations from your experiment to support your claim.
Reasoning: Did your observations support your claim? Describe, in detail, the connections between the evidence you gave and the claim you are making

Answers

Answer:

an organism is like a plant

Serotonin and Dopamine are 2 of the many neurotransmitters that are released when a synapse occurs.

A) true
B) False

Answers

Answer:

it is true

Explanation:

What is a fixed allele?
O A. An allele that mutates with each generation
B. An allele that is found on many genes
C. An allele present in all members of a population
ОО
D. An allele that formed by adaptive radiation

Answers

Answer:

C. An allele present in all members of a population

Explanation:

Just took the quiz

A fixed allele is an allele that is present in all members of a population and has a frequency of 100%. Therefore, option (C) is correct.

What is an allele?

An allele is a variant form of a gene that arises through mutation and is located on a specific location on a chromosome, known as a locus. Genes code for specific traits or characteristics, such as eye color or blood type, and alleles determine the variations of these traits.

For example, the gene that determines eye color has several different alleles, including blue, green, and brown, which produce different variations of the trait.

Alleles can be dominant, meaning that they are always expressed in the phenotype of an organism, or recessive, meaning that they are only expressed when paired with another recessive allele. The combination of alleles that an individual inherits from their parents determines their unique genotype and phenotype.

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Some researchers use fmri technology to study activity in the brain. What is the underlying activity detected by fmri?.

Answers

Some researchers use fMRI technology to study activity in the brain. The underlying activity detected by fMRI is by measuring the changes occurring in both oxygen amount present in the blood as well as the blood flow amount.

fMRI technology helps to detect the activity of the brain by measuring the changes occurring in both the amount of oxygen present in the blood as well as the amount of blood flow. This measurement is termed as the activity depending on the blood-oxygen level or called BOLD activity.

Functional magnetic resonance imaging or fMRI measures the activity of the brain by detecting various changes associated with the flow of blood. This technique will be relying on the fact of coupled activity of cerebral blood flow as well as neuronal activation. When an area of the brain is used up, there will be an increase in blood flow to that region.

The primary fMRI form uses contrast which is blood-oxygen-level dependent. This is a specialized brain type and a body scan that is used to map the activity of neurons in the brain or the spinal cord present in humans or in other animals by imaging the hemodynamic response which is related to the use of energy by the brain cells.

fMRI has come to dominate the mapping research of the brain as it does not involve injection uses, surgery, the ingestion of substances, and ionizing radiation exposure. This measure is usually corrupted by noise which is from various sources most frequently. Hence, the underlying signals are extracted by statistical procedures.

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__are to ribosomes as lipids are to__
A) Sugars; peroxisomes
B) Carbohydrates; rough endoplasmic reticulum
C) Nucleoli; lysosomes
D) Proteins; smooth endoplasmic reticulum

Answers

Proteins are to ribosomes as lipids are to smooth endoplasmic reticulum. Details about functions of organelles can be found below.

What are organelles?

Organelles are specialized structures in the cells of living organisms that perform specific functions in the cell.

Examples of organelles are as follows:

RibosomeNucleusEndoplasmic reticulumVacuolesMitochondria

However, ribosomes are involved in the synthesis of proteins while the smooth endoplasmic reticulum are directly involved in the synthesis of lipids.

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how would you determine the hardness of a mineral

Answers

Mohs Hardness Scale

Explanation:

A mineral's hardness is a measure of its relative resistance to scratching, measured by scratching the mineral against another substance of known hardness on the Mohs Hardness Scale.

The stage of meiosis where the chromosomes do not move apart equally and cause chromosomal abnormalities is

Answers

Answer: anaphase

Explanation: Nondisjunction can occur during anaphase of mitosis, meiosis I, or meiosis II. During anaphase, sister chromatids (or homologous chromosomes for meiosis I), will separate and move to opposite poles of the cell, pulled by microtubules

Hope this helps :)

How do enzymes support life functions of the cell and the body

Answers

Explanation:

Enzymes help speed up chemical reactions in the human body

The cell of the blood running though your blood cells

What are the similarities and differences between the two karyotypes?

Answers

Answer:

The typical human karyotypes contain 22 pairs of autosomal chromosomes and one pair of sex chromosomes (allosomes). The most common karyotypes for females contain two X chromosomes and are denoted 46,XX; males usually have both an X and a Y chromosome denoted 46,XY.

Explanation:

All of the following describe outcomes of urbanization except
O decreased soil pollution
O food chain disruption in a natural habitat
O increased wastewater from sewage drainage
O loss of plant biodiversity

Answers

Answer:

O decreased soil pollution

Explanation:

Urbanization does not lead to decreased soil pollution.

Pollution is the introduction of contaminants into the environments. As urbanization progresses and the population of people in a place increases, soil pollution increases.

Also, industrial expansion causes increased production of wastes. So, some of these wastes find their way into the environment of which the soil is a main component. There is an increased amount of soil pollution.

help!!!! i’ll give brainlest

Answers

Answer:

Lipids

Explanation:

Answer:

Lipids

Explanation:

a) Which country looks like it is experiencing exponential growth?
b) Which country looks like it has reached its carrying capacity?
c) Because it has reached its carrying capacity, describe the relationship between
its birth rates and death rates.
d) Describe what is happening to Europe's population size in terms of birth rates
and death rates.
e) Which country or countries could be experiencing:
emigration:
Explain your answer.
.
-immigration:
Explain your answer.

Answers

India has a sharp rising trend and a quickly growing population, so it appears to be growing exponentially. It seems that Japan's carrying capacity has been achieved.

How do population growth and carrying capacity relate to one another?

Growing populations may be impacted by increased density in a given area. The greatest number of a species that an ecosystem can sustain is referred to as the carrying capacity of a region. Carrying capacity is based on the amount of resources available (food, habitat, water).

What are some examples of exponential population growth?

The term for this quick trend of population rise is exponential expansion. The best illustration of exponential development is found in bacteria. Via prokaryotic fission, prokaryotes, such as bacteria, divide.

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